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Article

Low Dopamine D2 Receptor Increases Vulnerability to Obesity Via Reduced Physical Activity, Not Increased Appetitive Motivation.

Biological psychiatry - 1 Jun 2016

Beeler Jeff A, Faust Rudolf P, Turkson Susie, Ye Honggang, Zhuang Xiaoxi

Abstract excerpt

BACKGROUND: The dopamine D2 receptor (D2R) has received much attention in obesity studies. Data indicate that D2R is reduced in obesity and that the TaqA1 D2R variant may be more prevalent among obese persons. It is often suggested that reduced D2R generates a reward deficiency and altered appetitive motivation that induces compulsive eating and contributes to obesity. Although dopamine is known to regulate...

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Identifiers

PMID: 26281715
DOI: 10.1016/j.biopsych.2015.07.009
PMCID: PMC4728060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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