Cocaine and desipramine elicit distinct striatal noradrenergic and behavioral responses in selectively bred obesity-resistant and obesity-prone rats.

doi:10.1016/j.bbr.2017.11.009

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Article

Cocaine and desipramine elicit distinct striatal noradrenergic and behavioral responses in selectively bred obesity-resistant and obesity-prone rats.

Behavioural brain research - 2 Jul 2018

Vollbrecht Peter J, Nesbitt Kathryn M, Mabrouk Omar S, Chadderdon Aaron M, Jutkiewicz Emily M, Kennedy Robert T, Ferrario Carrie R

Abstract excerpt

Previous studies have demonstrated a role for norepinephrine (NE) in energy regulation and feeding, and basal differences have been observed in hypothalamic NE systems in obesity-prone vs. obesity-resistant rats. Differences in the function of brain reward circuits, including in the nucleus accumbens (NAc), have been shown in obesity-prone vs. obesity-resistant populations, leading many researchers to explore the...

Topics

Animals
Body Temperature
Central Nervous System Agents
Cocaine
Corpus Striatum
Desipramine
Dopamine
Eating
Genetic Predisposition to Disease
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Motor Activity

Norepinephrine

Norepinephrine Plasma Membrane Transport Proteins

Obesity

Rats

Serotonin

Species Specificity

Source

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Identifiers

PMID: 29129597
DOI: 10.1016/j.bbr.2017.11.009
PMCID: PMC5860948

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