Article
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 1997
Fei H, Okano H J, Li C, Lee G H, Zhao C, Darnell R, Friedman J M
Abstract excerpt
Leptin's effects are mediated by interactions with a receptor that is alternatively spliced, resulting in at least five different murine forms: Ob-Ra, Ob-Rb, Ob-Rc, Ob-Rd, and Ob-Re. A mutation in one splice form, Ob-Rb, results in obesity in mice. Northern blots, RNase protection assays, and PCR indicate that Ob-Rb is expressed at a relatively high level in hypothalamus and low level in several other tissues....
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