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Article

Leptin deficiency produces contrasting phenotypes in bones of the limb and spine.

Bone - 1 Mar 2004

Hamrick M W, Pennington C, Newton D, Xie D, Isales C

Abstract excerpt

Leptin is a hormone secreted by adipocytes that can regulate bone mass through a central, neuroendocrine signaling pathway. We tested the hypothesis that the response of bone tissue to altered leptin signaling is not uniform throughout the skeleton, but may vary between different skeletal regions and between cortical and trabecular moieties. We investigated the effects of leptin deficiency on muscle mass and bone...

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Identifiers

PMID: 15003785
DOI: 10.1016/j.bone.2003.11.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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