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Article

IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice.

Endocrinology - 1 Mar 2014

Neumann Ursula H, Chen Sam, Tam Yuen Yi C, Baker Robert K, Covey Scott D, Cullis Pieter R, Kieffer Timothy J

Abstract excerpt

The ability of leptin to improve metabolic abnormalities in models of leptin deficiency, lipodystrophy, and even type 1 diabetes is of significant interest. However, the mechanism by which leptin mediates these effects remains ill-defined. Leptin was recently reported to regulate insulin-like growth factor-binding protein-2 (IGFBP2), and adenoviral overexpression of pharmacological levels of IGFBP2 ameliorates...

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Source

Identifiers

PMID: 24424049
DOI: 10.1210/en.2013-1622

Genes

IGFBP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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