Article
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing.
Human molecular genetics - 1 Nov 2009
Wang Yipeng, Martinez-Vicente Marta, Krüger Ulrike, Kaushik Susmita, Wong Esther, Mandelkow Eva-Maria, Cuervo Ana Maria, Mandelkow Eckhard
Abstract excerpt
Aggregation and cleavage are two hallmarks of Tau pathology in Alzheimer disease (AD), and abnormal fragmentation of Tau is thought to contribute to the nucleation of Tau paired helical filaments. Clearance of the abnormally modified protein could occur by the ubiquitin-proteasome and autophagy-lysosomal pathways, the two major routes for protein degradation in cells. There is a debate on which of these pathways...
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