Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirement of Src Kinase Lyn for Induction of DNA Synthesis by Granulocyte Colony-stimulating Factor

1 Feb 1998

Abstract excerpt

Treatment of cells with granulocyte colony-stimulating factor (G-CSF) leads to tyrosine phosphorylation of cellular proteins. G-CSF stimulates both the activation of protein tyrosine kinases Lyn, Jak1, and Jak2 and the association of these enzymes with the G-CSF receptor. Wild-type, lyn-deficient, and syk-deficient chicken B lymphocyte cell lines were transfected with the human G-CSF receptor, and stable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Cytokine Signaling Pathways and Interactions
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9452436
DOI: 10.1074/jbc.273.6.3230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement of Src Kinase Lyn for Induction of DNA Synthesis by Granulocyte Colony-stimulating FactorPMID 9452436Read ↗

Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.Semantic proximity Read ↗

Mutation of the Lyn tyrosine kinase delays the progression of Friend virus induced erythroleukemia without affecting susceptibility.Semantic proximity Read ↗

Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus.Semantic proximity Read ↗

SH3 domains specifically regulate kinase activity of expressed Src family proteins.Semantic proximity Read ↗

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage.Semantic proximity Read ↗

Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration.Semantic proximity Read ↗

Induction of growth factor-independence and GM-CSF secretion by the v-src oncogene in murine myeloid cells does not require membrane association of pp60v-src.Semantic proximity Read ↗

Stimulation of c-Src by prolactin is independent of Jak2.Semantic proximity Read ↗

Expression of a Y559F mutant CSF-1 receptor in M1 myeloid cells: a role for Src kinases in CSF-1 receptor-mediated differentiation.Semantic proximity Read ↗

Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition.Semantic proximity Read ↗

Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage.Semantic proximity Read ↗

Role of Gas1 down-regulation in mitogenic stimulation of quiescent NIH3T3 cells by v-Src.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.