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Article

Presenilin-1 familial Alzheimer's disease mutation alters hippocampal neurogenesis and memory function in CCL2 null mice.

Brain, behavior, and immunity - 1 Oct 2015

Kiyota Tomomi, Morrison Christine M, Tu Guihua, Dyavarshetty Bhagyalaxmi, Weir Robert A, Zhang Gang, Xiong Huangui, Gendelman Howard E

Abstract excerpt

Aberrations in hippocampal neurogenesis are associated with learning and memory, synaptic plasticity and neurodegeneration in Alzheimer's disease (AD). However, the linkage between them, β-amyloidosis and neuroinflammation is not well understood. To this end, we generated a mouse overexpressing familial AD (FAD) mutant human presenilin-1 (PS1) crossed with a knockout (KO) of the CC-chemokine ligand 2 (CCL2) gene....

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Identifiers

PMID: 26112421
DOI: 10.1016/j.bbi.2015.06.014
PMCID: PMC4567522

Genes

CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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