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Article

Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation.

The American journal of pathology - 1 Jul 2005

Chevallier Nathalie L, Soriano Salvador, Kang David E, Masliah Eliezer, Hu Gloria, Koo Edward H

Abstract excerpt

In addition to its well-established role in gamma-secretase cleavage, presenilin (PS) also plays a role in regulating the stability of cytosolic beta-catenin, a protein involved in Wnt signaling. Several familial Alzheimer's disease-associated PS1 mutations have been shown to increase the stability of the signaling pool of beta-catenin, correlating with enhanced cell proliferation. Accordingly, we hypothesized...

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Identifiers

PMID: 15972961
DOI: 10.1016/S0002-9440(10)62962-8
PMCID: PMC1603433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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