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Article

A genetic epilepsy rat model displays endophenotypes of psychosis.

Neurobiology of disease - 1 Jul 2010

Jones Nigel C, Martin Sally, Megatia Ika, Hakami Tahir, Salzberg Michael R, Pinault Didier, Morris Margaret J, O'Brien Terence J, van den Buuse Maarten

Abstract excerpt

The incidence of psychosis is increased in people with epilepsy, including idiopathic generalized epilepsies. To study the biological basis for this co-morbidity, we compared GAERS, a genetic rat model of absence epilepsy, to non-epileptic control rats (NEC). Mature, 14-week old GAERS showed enhanced amphetamine-induced locomotor hyperactivity - a feature also present in young (6-week old) GAERS prior to epilepsy...

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Source

Identifiers

PMID: 20153428
DOI: 10.1016/j.nbd.2010.02.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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