Genetically seizure-prone or seizure-resistant phenotypes and their associated behavioral comorbidities.

doi:10.1111/j.1528-1167.2007.01398.x

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Article

Genetically seizure-prone or seizure-resistant phenotypes and their associated behavioral comorbidities.

Epilepsia - 1 Jan 2007

McIntyre Dan C, Gilby Krista L

Abstract excerpt

It was questioned whether amygdala kindling, a model of temporal lobe epilepsy, is under genetic control, and is associated with comorbid behavioral features. Initially, rats were selectively bred for speed of amygdala kindling, and, in subsequent generations, were assessed in behavioral paradigms to measure activity, emotionality, impulsivity, and learning. Clearly kindling was under genetic control, as two...

Topics

Amygdala
Animals
Attention Deficit Disorder with Hyperactivity
Behavior, Animal
Breeding
Comorbidity
Disease Models, Animal
Epilepsy, Temporal Lobe
Humans
Kindling, Neurologic
Phenotype
Rats
Rats, Long-Evans
Rats, Wistar
Seizures
Selection, Genetic

Source

Open in PubMed

Identifiers

PMID: 18047598
DOI: 10.1111/j.1528-1167.2007.01398.x

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