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Article

The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities

9 Nov 2022

Abstract excerpt

This review discusses the long-term effects of early-life environment on epileptogenesis, epilepsy, and neuropsychiatric comorbidities with an emphasis on the absence epilepsy. The WAG/Rij rat strain is a well-validated genetic model of absence epilepsy with mild depression-like (dysthymia) comorbidity. Although pathologic phenotype in WAG/Rij rats is genetically determined, convincing evidence presented in this...

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Identifiers

PMID: 36386598
DOI: 10.1016/j.ibneur.2022.10.012

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