Back to search

Article

Gestational valproate exposure induces tissue-specific transcriptomic changes in the neonatal brain and choroid plexus in a rat model of epilepsy, GAERS

2025-02-27

Abstract excerpt

Valproate is an antiseizure drug required by many epileptic patients to manage their symptoms. During pregnancy, its use has been shown to increase the risk of neurobehavioral deficits in the offspring. The present study used a rat model of absence epilepsy, Genetic Absence Epilepsy Rat from Strasbourg (GAERS), to investigate effects of gestational valproate exposure on early postnatal brain cortex and lateral cho...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
64dae84c-ead7-5aa6-ac51-5416670d377e
DOI
10.22541/au.174065833.31753034/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Gestational valproate exposure induces tissue-specific transcriptomic changes in the neonatal brain and choroid plexus in a rat model of epilepsy, GAERSDOI 10.22541/au.174065833.31753034/v1
Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disabilitySemantic proximity
Rapid effects of valproic acid on the fetal brain transcriptome: Implications for brain development and autismSemantic proximity
In utero Exposure to Valproic Acid throughout Pregnancy Causes Phenotypes of Autism in Offspring Mice.Semantic proximity
Rapid effects of valproic acid on the fetal brain transcriptome: Implications for brain development and autismSemantic proximity
RNA‑seq analysis of blood of valproic acid‑responsive and non‑responsive pediatric patients with epilepsySemantic proximity
Sex differences in physiological response to increased neuronal excitability in a knockin mouse model of pediatric epilepsy.Semantic proximity
Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primatesSemantic proximity
The epilepsy–autism phenotype associated with developmental and epileptic encephalopathies: New mechanism‐based therapeutic optionsSemantic proximity
Gestational hypertension increases risk of seizures in children and miceSemantic proximity
A scientific review: mechanisms of valproate-mediated teratogenesisSemantic proximity
Ectopic neurogenesis induced by prenatal antiepileptic drug exposure augments seizure susceptibility in adult miceSemantic proximity
Mutations of protocadherin 19 in female epilepsy (PCDH19-FE) lead to allopregnanolone deficiency.Semantic proximity
Select a neighboring publication to make it the new centre.