Active hepatitis B virus replication in the presence of anti-HBe is associated with viral variants containing an inactive pre-C region.

doi:10.1016/0042-6822(90)90030-u

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Article

Active hepatitis B virus replication in the presence of anti-HBe is associated with viral variants containing an inactive pre-C region.

Virology - 1 Jun 1990

Tong S P, Li J S, Vitvitski L, Trépo C

Abstract excerpt

Although rise of anti-HBe immunity in the course of hepatitis B virus (HBV) infection is generally followed by clearance of the infectious virions, ongoing chronic liver disease with circulating virions has been repeatedly observed in a significant number of anti-HBe patients, especially in Medit...

Topics

Base Sequence
Cloning, Molecular
DNA, Viral
Hepatitis B
Hepatitis B Antibodies
Hepatitis B Core Antigens
Hepatitis B e Antigens
Hepatitis B virus
Hepatitis, Chronic
Humans
Immune Sera
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Restriction Mapping
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 2345966
DOI: 10.1016/0042-6822(90)90030-u

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2345966-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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