Article
The complete nucleotide sequence of a pre-core mutant of hepatitis B virus implicated in fulminant hepatitis and its biological characterization in chimpanzees.
Virology - 1 May 1993
Ogata N, Miller R H, Ishak K G, Purcell R H
Abstract excerpt
Hepatitis B virus (HBV) with an in-frame stop codon within the pre-core region of the virus genome caused fulminant hepatitis in two individuals. Serum from a chronically infected patient who was the source of the virus was inoculated into three chimpanzees at dilutions of 10(-1), 10(-3), and 10(...
Topics
- Animals
- Base Sequence
- Consensus Sequence
- Genetic Variation
- Hepatic Encephalopathy
- Hepatitis B
- Hepatitis B virus
- Humans
- Infant
- Liver
- Molecular Sequence Data
- Nucleic Acid Conformation
- Pan troglodytes
- Polymerase Chain Reaction
- Protein Precursors
- Regulatory Sequences, Nucleic Acid
- Sequence Analysis, DNA
- Sequence Homology, Amino Acid