Article
A precore-defective mutant of hepatitis B virus associated with e antigen-negative chronic liver disease.
Journal of medical virology - 1 Oct 1990
Ulrich P P, Bhat R A, Kelly I, Brunetto M R, Bonino F, Vyas G N
Abstract excerpt
The pathogenesis of chronic liver disease (CLD) due to persistent hepatitis B virus (HBV) infection has not been defined, but the disease activity is believed to correlate with the presence of hepatitis B e-antigen (HBeAg) antigenemia and high viremia. The molecular characterization of an HBV mut...
Topics
- Adult
- Base Sequence
- Chronic Disease
- Cloning, Molecular
- DNA, Viral
- Hepatitis B
- Hepatitis B e Antigens
- Hepatitis B virus
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Protein Biosynthesis
- Terminator Regions, Genetic
- Virus Replication