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Article

A precore-defective mutant of hepatitis B virus associated with e antigen-negative chronic liver disease.

Journal of medical virology - 1 Oct 1990

Ulrich P P, Bhat R A, Kelly I, Brunetto M R, Bonino F, Vyas G N

Abstract excerpt

The pathogenesis of chronic liver disease (CLD) due to persistent hepatitis B virus (HBV) infection has not been defined, but the disease activity is believed to correlate with the presence of hepatitis B e-antigen (HBeAg) antigenemia and high viremia. The molecular characterization of an HBV mutant isolated from an HBeAg-negative patient with severe CLD required amplification of the circulating HBV DNA (2 pg/ml)...

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Source

Identifiers

PMID: 2280256
DOI: 10.1002/jmv.1890320208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A precore-defective mutant of hepatitis B virus associated with e antigen-negative chronic liver disease.PMID 2280256Read ↗

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