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Article

In vitro and in vivo replication capacity of the precore region defective hepatitis B virus variants.

Journal of hepatology - 1 Jan 1991

Tong S P, Brotman B, Li J S, Vitvitski L, Pascal D, Prince A M, Trépo C

Abstract excerpt

Although the precore region defective hepatitis B virus variants have been implicated in chronic liver disease and fulminant hepatitis, our knowledge on the molecular biology of these variants is still limited. Using an in vitro transfection assay, we confirmed the replication competent but HBeAg-negative nature of the major variants containing a TAG stop codon in the distal precore region associated with one or...

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Identifiers

PMID: 1668333
DOI: 10.1016/0168-8278(91)90028-a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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