In vitro and in vivo replication capacity of the precore region defective hepatitis B virus variants.

doi:10.1016/0168-8278(91)90028-a

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Article

In vitro and in vivo replication capacity of the precore region defective hepatitis B virus variants.

Journal of hepatology - 1 Jan 1991

Tong S P, Brotman B, Li J S, Vitvitski L, Pascal D, Prince A M, Trépo C

Abstract excerpt

Although the precore region defective hepatitis B virus variants have been implicated in chronic liver disease and fulminant hepatitis, our knowledge on the molecular biology of these variants is still limited. Using an in vitro transfection assay, we confirmed the replication competent but HBeAg...

Topics

Animals
Base Sequence
Carcinoma, Hepatocellular
Defective Viruses
Genetic Variation
Hepatitis B virus
Humans
Liver Neoplasms
Molecular Sequence Data
Mutagenesis, Site-Directed
Pan troglodytes
RNA, Messenger
Transfection
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 1668333
DOI: 10.1016/0168-8278(91)90028-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1668333-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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