Article
Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease.
Mechanisms of ageing and development - 1 Mar 2010
Dachsel Justus C, Nishioka Kenya, Vilariño-Güell Carles, Lincoln Sarah J, Soto-Ortolaza Alexandra I, Kachergus Jennifer, Hinkle Kelly M, Heckman Michael G, Jasinska-Myga Barbara, Taylor Julie P, Dickson Dennis W, Gibson Rachel A, Hentati Faycal, Ross Owen A, Farrer Matthew J
Abstract excerpt
LRRK2 mutations are recognized as the most frequent genetic cause of both familial and sporadic parkinsonism identified to date. A remarkable feature of this form of parkinsonism is the variable penetrance of symptom manifestation resulting in a wide range of age-at-onset in patients. Herein we use a functional approach to identify the Lrrk1 protein as a potential disease modifier demonstrating an interaction and...
Topics
- Age of Onset
- Humans
- Mutation
- Parkinson Disease
- Parkinsonian Disorders
- Penetrance
- Protein Multimerization