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Article

Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1.

Cell metabolism - 3 Feb 2010

Yamada Eijiro, Pessin Jeffrey E, Kurland Irwin J, Schwartz Gary J, Bastie Claire C

Abstract excerpt

Fyn null mice display reduced adiposity associated with increased fatty acid oxidation, energy expenditure, and activation of the AMP-dependent protein kinase (AMPK) in skeletal muscle and adipose tissue. The acute pharmacological inhibition of Fyn kinase activity with SU6656 in wild-type mice re...

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Identifiers

PMID: 20142099
DOI: 10.1016/j.cmet.2009.12.010
PMCID: PMC2830006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20142099-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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