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A genetic variant in the gene encoding fibrinogen beta chain predicted development of hypertension in Chinese men.

Thrombosis and haemostasis - 1 Apr 2010

Ong Kwok Leung, Tso Annette W K, Cherny Stacey S, Sham Pak Chung, Lam Karen S L, Jiang Chao Qiang, Thomas G Neil, Lam Tai Hing, Cheung Bernard M Y

Abstract excerpt

Fibrinogen, a major determinant of blood viscosity, is an acute phase protein associated with cardiovascular disease. We studied the association of hypertension with single nucleotide polymorphisms (SNPs) in the gene encoding the fibrinogen beta chain (FGB). Three tagging SNPs (rs1025154, rs4220 and rs1044291) were selected from the HapMap database on Han Chinese. Genotypes were determined in 1,294 unrelated...

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PMID: 20135074
DOI: 10.1160/TH09-10-0692

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FGB

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