Article
Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors.
Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2010
Dixon Claire I, Morris Hannah V, Breen Gerome, Desrivieres Sylvane, Jugurnauth Sarah, Steiner Rebecca C, Vallada Homero, Guindalini Camila, Laranjeira Ronaldo, Messas Guilherme, Rosahl Thomas W, Atack John R, Peden Dianne R, Belelli Delia, Lambert Jeremy J, King Sarah L, Schumann Gunter, Stephens David N
Abstract excerpt
Because GABA(A) receptors containing alpha2 subunits are highly represented in areas of the brain, such as nucleus accumbens (NAcc), frontal cortex, and amygdala, regions intimately involved in signaling motivation and reward, we hypothesized that manipulations of this receptor subtype would infl...
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