Article
Deletion of the GABAA α2-subunit does not alter self administration of cocaine or reinstatement of cocaine seeking.
Psychopharmacology - 1 Jul 2014
Dixon C I, Halbout B, King S L, Stephens D N
Abstract excerpt
RATIONALE: GABAA receptors containing α2-subunits are highly represented in brain areas that are involved in motivation and reward, and have been associated with addiction to several drugs, including cocaine. We have shown previously that a deletion of the α2-subunit results in an absence of sensitisation to cocaine. OBJECTIVE: We investigated the reinforcing properties of cocaine in GABAA α2-subunit knockout...
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