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Article

Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition.

Clinical and experimental immunology - 1 Jun 2010

Choi R Y, Farquhar C, Juno J, Mbori-Ngacha D, Lohman-Payne B, Vouriot F, Wayne S, Tuff J, Bosire R, John-Stewart G, Fowke K

Abstract excerpt

The C868T single nucleotide polymorphism (SNP) in the CD4 receptor encodes an amino acid change that could alter its structure and influence human immunodeficiency virus (HIV-1) infection risk. HIV-1-infected pregnant women in Nairobi were followed with their infants for 1 year postpartum. Among 131 infants, those with the 868T allele were more likely than wild-type infants to acquire HIV-1 overall [hazard ratio...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20132229
DOI: 10.1111/j.1365-2249.2010.04096.x
PMCID: PMC2883118

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