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Article

KIR2DS4 allelic variants: Differential effects on in utero and intrapartum HIV-1 mother-to-child transmission.

Clinical immunology (Orlando, Fla.) - 1 Dec 2013

Hong Heather A, Paximadis Maria, Gray Glenda E, Kuhn Louise, Tiemessen Caroline T

Abstract excerpt

KIR2DS4 is the only activating gene within the A haplotype, and alleles of KIR2DS4 can encode either functional (KIR2DS4-f) or non-functional (KIR2DS4-v) variants. To establish the role of KIR2DS4 in the context of HIV-1 mother-to-child transmission, we KIR genotyped 145 HIV-1 non-transmitting mothers (NT) and their exposed uninfected infants (EU), and 72 HIV-1 transmitting mothers (TR) and their infected infants...

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Identifiers

PMID: 24239756
DOI: 10.1016/j.clim.2013.09.005

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