Dominant‐negative derivative of EBNA1 represses EBNA1‐mediated transforming gene expression during the acute phase of Epstein–Barr virus infection independent of rapid loss of viral genome

Abstract excerpt

The oncogenic human herpes virus, the Epstein-Barr virus (EBV), expresses EBNA1 in almost all forms of viral latency. EBNA1 plays a major role in the maintenance of the viral genome and in the transactivation of viral transforming genes, including EBNA2 and latent membrane protein (LMP-1). However, it is unknown whether inhibition of EBNA1 from the onset of EBV infection disrupts the establishment of EBV's...

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