Article
Oncogenesis of CAEBV revealed: Intragenic deletions in the viral genome and leaky expression of lytic genes
17 Dec 2019
Abstract excerpt
Epstein-Barr virus (EBV) is a causative agent of infectious mononucleosis and several malignancies involving lymphocytes and epithelial cells. We recently reported genomic analyses of chronic active EBV infection (CAEBV), a proliferative disorder of T and/or NK cells, as well as other lymphoid malignancies. We found that T and/or NK cells undergoing clonal expansion in CAEBV patients gain somatic driver mutations...
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