Article
Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genes.
Proceedings of the National Academy of Sciences of the United States of America - 19 Sept 2006
Altmann Markus, Pich Dagmar, Ruiss Romana, Wang Jindong, Sugden Bill, Hammerschmidt Wolfgang
Abstract excerpt
EBV is a paradigm for human tumor viruses because, although it infects most people benignly, it also can cause a variety of cancers. Both in vivo and in vitro, EBV infects B lymphocytes in G0, induces them to become blasts, and can maintain their proliferation in cell culture or in vivo as tumors. How EBV succeeds in these contrasting cellular environments in expressing its genes that control the host has not...
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