Article

Dissecting Epstein–Barr Virus Dependence Across Diverse Infected Cell Models

2025-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Epstein–Barr virus (EBV) is maintained clonally in a wide array of tumors and cells of lymphoproliferative disorders, yet the degree to which these infected cells continuously depend on EBV remains unresolved. To directly assess EBV dependence, we used two complementary Cas9-based viral eviction strategies: 1) targeting EBNA1 to promote episome dilution during cell division, and 2) targeting rep...

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Literature Corpus work: 0461217e-d906-5d51-ae7c-f624f1d971d5
DOI: 10.64898/2025.12.19.695354

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