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Article

Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Apr 2005

Nasimuzzaman Md, Kuroda Masayuki, Dohno Sumitaka, Yamamoto Takenobu, Iwatsuki Keiji, Matsuzaki Shigenobu, Mohammad Rashel, Kumita Wakako, Mizuguchi Hiroyuki, Hayakawa Takao, Nakamura Hiroyuki, Taguchi Takahiro, Wakiguchi Hiroshi, Imai Shosuke

Abstract excerpt

Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1), a latent viral protein consistently expressed in infected proliferating cells, is essentially required in trans to maintain EBV episomes in cells. We constructed a mutant (mt) EBNA1 and examined whether it exerted dominant-negative effects on maintenance of the viral episome thereby leading to abrogation of EBV-infected tumor cell growth. Using lymphocyte and...

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Identifiers

PMID: 15771960
DOI: 10.1016/j.ymthe.2004.12.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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