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EBV persistence without its EBNA3A and 3C oncogenes in vivo

30 Apr 2018

Abstract excerpt

The oncogenic Epstein Barr virus (EBV) infects the majority of the human population and usually persists within its host for life without symptoms. The EBV oncoproteins nuclear antigen 3A (EBNA3A) and 3C (EBNA3C) are required for B cell transformation in vitro and are expressed in EBV associated immunoblastic lymphomas in vivo. In order to address the necessity of EBNA3A and EBNA3C for persistent EBV infection in...

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PMID: 29709016
DOI: 10.1371/journal.ppat.1007039

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