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The Cooperative Functions of the EBNA3 Proteins Are Central to EBV Persistence and Latency

17 Mar 2018

Abstract excerpt

The Epstein-Barr nuclear antigen 3 (EBNA3) family of proteins, comprising EBNA3A, EBNA3B, and EBNA3C, play pivotal roles in the asymptomatic persistence and life-long latency of Epstein-Barr virus (EBV) in the worldwide human population. EBNA3-mediated transcriptional reprogramming of numerous host cell genes promotes in vitro B cell transformation and EBV persistence in vivo. Despite structural and sequence...

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PMID: 29562595
DOI: 10.3390/pathogens7010031

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