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Article

The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold

28 Aug 2003

Abstract excerpt

The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is one of the earliest viral proteins expressed after infection and is the only latent protein consistently expressed in viral-associated tumors. EBNA1's crucial role in viral DNA replication, episomal maintenance, and partitioning is well examined whereas its importance for the immortalization process and the tumorgenicity of EBV is unclear. To address these...

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PMID: 12947043
DOI: 10.1073/pnas.1832776100

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