Article
Protective effect of HLA-DRB1*13 alleles during specific phases in the development of ACPA-positive RA.
Annals of the rheumatic diseases - 1 Oct 2016
van Heemst Jurgen, Hensvold Aase H, Jiang Xia, van Steenbergen Hanna, Klareskog Lars, Huizinga Tom W J, van der Helm-van Mil Annette, Catrina Anca I, Toes René E M, Lundberg Karin, van der Woude Diane
Abstract excerpt
OBJECTIVE: Human leucocyte antigen (HLA)-DRB1*13 alleles are associated with protection from anticitrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA). It is, however, unknown at which phase of disease development (seroconversion, ACPA maturation, disease onset or outcome) these alleles are most important. We therefore examined the effect of HLA-DRB1*13 on: ACPA presence (systemic autoimmunity...
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