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Article

Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor.

Arthritis research & therapy - 1 Jan 2010

Balsa Alejandro, Cabezón Arancha, Orozco Gisela, Cobo Tatiana, Miranda-Carus Eugenia, López-Nevot Miguel Angel, Vicario José Luis, Martín-Mola Emilio, Martín Javier, Pascual-Salcedo Dora

Abstract excerpt

INTRODUCTION: The purpose of this study was to investigate the association between HLA-DRB1 alleles with susceptibility to rheumatoid arthritis (RA) and production of antibodies against citrullinated proteins (ACPA) and rheumatoid factor (RF). METHODS: We studied 408 patients (235 with RA, 173 non-RA) and 269 controls. ACPA, RF and HLA-DR typing were determined. RESULTS: We found an increased frequency of HLA...

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Identifiers

PMID: 20370905
DOI: 10.1186/ar2975
PMCID: PMC2888213

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Source receipt: pubmed, retrieved 7 Sept 2026.

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