Article
Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma?
The Lancet. Oncology - 1 Jan 2011
Kloosterhof Nanne K, Bralten Linda B C, Dubbink Hendrikus J, French Pim J, van den Bent Martin J
Abstract excerpt
The discovery of somatic mutations in the gene encoding isocitrate dehydrogenase-1 (IDH1) in glioblastomas was remarkable because the enzyme was not previously identified with any known oncogenic pathway. IDH1 is mutated in up to 75% of grade II and grade III diffuse gliomas. Apart from acute myeloid leukaemia, other tumour types do not carry IDH1 mutations. Mutations in a homologous gene, IDH2, have also been...
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