Article
Isocitrate dehydrogenase mutations in diffuse gliomas: clinical and aetiological implications.
Journal of clinical pathology - 1 Oct 2011
Gupta R, Webb-Myers R, Flanagan S, Buckland M E
Abstract excerpt
The discovery of isocitrate dehydrogenase (IDH) mutations in gliomas is one example of the large impact that next-generation sequencing is having on the understanding of tumour biology and human disease in general. IDH mutations are early and common events in the development of astrocytomas, oligodendrogliomas and oligoastrocytomas. IDH mutations are also found in some myeloid malignancies and soft tissue...
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