Article
Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice.
Investigative ophthalmology & visual science - 1 Jul 2010
Bobbie Michael W, Roy Sumon, Trudeau Kyle, Munger Stephanie J, Simon Alexander M, Roy Sayon
Abstract excerpt
PURPOSE. To examine whether diabetes-induced connexin 43 downregulation promotes retinal vascular lesions characteristic of diabetic retinopathy (DR). METHODS. Two animal models, streptozotocin-induced diabetic mice and Cx43 heterozygous knockout (Cx43(+/-)) mice, were studied to directly assess whether diabetes reduces the expression of retinal Cx43, which, in turn, contributes to retinal vascular cell loss by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.