Article

Residual Dp71 Expression Is Sufficient to Preserve Retinal Vascular Homeostasis in a Mouse Model of Duchenne Muscular Dystrophy

2026-01-21

Abstract excerpt

The dystrophin gene encodes multiple dystrophin isoforms with tissue-specific functions, including several shorter isoforms expressed in the central nervous system and retina. While Duchenne muscular dystrophy (DMD) has historically been charac-terized as a primary myopathy resulting from loss of the full-length dystrophin Dp427, increasing clinical evidence indicates that dysfunction of shorter dystrophin isoform...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7f0530fb-7c57-5802-8c2b-c417e412fa84
DOI: 10.20944/preprints202601.1560.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Residual Dp71 Expression Is Sufficient to Preserve Retinal Vascular Homeostasis in a Mouse Model of Duchenne Muscular DystrophyDOI 10.20944/preprints202601.1560.v1Read

Localization of dystrophin isoform Dp71 to the inner limiting membrane of the retina suggests a unique functional contribution of Dp71 in the retina.Semantic proximity Read

Targeted inactivation of dystrophin gene product Dp71: phenotypic impact in mouse retina.Semantic proximity Read

The Multi-System Roles of Dp71 Dystrophin Isoforms in Duchenne Muscular DystrophySemantic proximity Read

Dystrophin Dp71 is essential for the development and function of macrophagesSemantic proximity Read

Endothelial Cell–Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact VasculatureSemantic proximity Read

Prevention of dystrophic pathology in mdx mice by a truncated dystrophin isoform.Semantic proximity Read

Blockade of VEGFR1 and 2 Suppresses Pathological Angiogenesis and Vascular Leakage in the EyeSemantic proximity Read

An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillarisSemantic proximity Read

Targeted deletion of Vegfa in adult mice induces vision lossSemantic proximity Read

Detection of Dystrophin Dp71 in Human Skeletal Muscle Using an Automated Capillary Western Assay SystemSemantic proximity Read

Müller cell‐derived VEGF is a significant contributor to retinal neovascularizationSemantic proximity Read

Cloning and characterization of alternatively spliced isoforms of Dp71Semantic proximity Read