Article
VEGF-induced choroidal damage in a murine model of retinal neovascularisation.
The British journal of ophthalmology - 1 Jun 2008
Tee L B G, Penrose M A, O'Shea J E, Lai C-M, Rakoczy E P, Dunlop S A
Abstract excerpt
BACKGROUND/AIMS: Photoreceptor-specific upregulation of vascular endothelial growth factor (VEGF) in a transgenic mouse model (Kimba) of retinal neovascularisation induces retinal vascular damage which appears similar to that in diabetic retinopathy. Here we have determined whether the choroidal vasculature is also affected in Kimba. METHODS: Kimba mice were assessed with fundus fluorescein angiography for mild,...
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