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Article

Interruption of Wnt signaling in Müller cells ameliorates ischemia-induced retinal neovascularization.

PloS one - 1 Jan 2014

Zhou Kelu Kevin, Benyajati Siribhinya, Le Yun, Cheng Rui, Zhang Wenbo, Ma Jian-xing

Abstract excerpt

Retinal Müller cells are major producers of inflammatory and angiogenic cytokines which contribute to diabetic retinopathy (DR). Over-activation of the Wnt/β-catenin pathway has been shown to play an important pathogenic role in DR. However, the roles of Müller cell-derived Wnt/β-catenin signaling in retinal neovascularization (NV) and DR remain undefined. In the present study, mice with conditional β-catenin...

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Identifiers

PMID: 25271989
DOI: 10.1371/journal.pone.0108454
PMCID: PMC4182699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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