Article
TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis.
Investigative ophthalmology & visual science - 1 Mar 2011
Huang Hu, Gandhi Jarel K, Zhong Xiufeng, Wei Yanhong, Gong Junsong, Duh Elia J, Vinores Stanley A
Abstract excerpt
PURPOSE: Blood-retinal barrier [BRB] breakdown, characteristic of diabetic retinopathy (DR), is believed to depend on inflammation and apoptosis. Retinal inflammation is almost completely suppressed in the absence of TNFα, which is also associated with apoptosis. This study was conducted to determine the role of TNFα in these diabetic complications. METHODS: Diabetes was induced with streptozotocin in Tnfa...
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