Article
Multiple degradation pathways for misfolded mutants of the yeast plasma membrane ATPase, Pma1.
The Journal of biological chemistry - 20 Oct 2006
Liu Yu, Sitaraman Sujatha, Chang Amy
Abstract excerpt
To understand protein sorting and quality control in the secretory pathway, we have analyzed intracellular trafficking of the yeast plasma membrane ATPase, Pma1. Pma1 is ideal for such studies because it is a very abundant polytopic membrane protein, and its localization and activity at the plasma membrane are essential for cell viability and growth. We have tested whether the cytoplasmic amino- and...
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