Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low level of the mtDNA(4977) deletion in blood of exceptionally old individuals.

Mechanisms of ageing and development - 1 Mar 2010

von Wurmb-Schwark Nicole, Schwark Thorsten, Caliebe Amke, Drenske Carolin, Nikolaus Susanna, Schreiber Stefan, Nebel Almut

Abstract excerpt

The common 4977-bp deletion in mitochondrial DNA (dmtDNA(4977)) occurs frequently in tissues of high oxygen demand and low mitotic activity, e.g. brain, heart and skeletal muscle, where it appears to show an age-related accumulation. Although dmtDNA(4977) can also be detected in very low amounts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Distribution
Share to Aging
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria

Share to Muscle, Skeletal

Share to Sequence Deletion

Share to Smoking

Source

Identifiers

PMID: 20117127
DOI: 10.1016/j.mad.2010.01.005

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20117127-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low level of the mtDNA(4977) deletion in blood of exceptionally old individuals.PMID 20117127Read ↗

Detection of mtDNA with 4977 bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease.Semantic proximity Read ↗

A specific 4977-bp deletion of mitochondrial DNA in human ageing skin.Semantic proximity Read ↗

The impact of mitochondrial DNA on human lifespan: a view from studies on centenarians.Semantic proximity Read ↗

The molecular biomarkers of vascular aging and atherosclerosis: telomere length and mitochondrial DNA4977 common deletionSemantic proximity Read ↗

Deleterious mitochondrial DNA mutations accumulate in aging human tissues.Semantic proximity Read ↗

Prognostic value of mitochondrial DNA4977 deletion and mitochondrial DNA copy number in patients with stable coronary artery disease.Semantic proximity Read ↗

Mitochondrial DNA Common Deletion in Cancer: Emerging Evidence and Methodological ChallengesSemantic proximity Read ↗

Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing.Semantic proximity Read ↗

mtDNA mutations in human aging and longevity: controversies and new perspectives opened by high-throughput technologies.Semantic proximity Read ↗

A study of mitochondrial DNA mutations in peripheral lymphocytes in an aging cohort.Semantic proximity Read ↗

A new human mtDNA polymorphism: MTND6: 14562 (C-->T).Semantic proximity Read ↗

Independent impacts of aging on mitochondrial DNA quantity and quality in humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.