Article
Detection of mtDNA with 4977 bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease.
Mutation research - 15 Feb 2005
Botto Nicoletta, Berti Sergio, Manfredi Samantha, Al-Jabri Anees, Federici Chiara, Clerico Aldo, Ciofini Enrica, Biagini Andrea, Andreassi Maria Grazia
Abstract excerpt
Recent evidence suggests that somatic mutations in nuclear and mitochondrial DNA accumulated during aging, may significantly contribute to the pathogenesis of chronic-degenerative illness such as coronary artery disease (CAD). Mitochondrial DNA with 4977 bp deletion mutation (mtDNA4977) is a common type of mtDNA alteration in humans. However, little attempt has been made to detect the presence of mtDNA4977...
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