Article
A specific 4977-bp deletion of mitochondrial DNA in human ageing skin.
Archives of dermatological research - 1 Jan 1994
Yang J H, Lee H C, Lin K J, Wei Y H
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations have recently been proposed as important contributors to ageing and degenerative diseases. In this study, we applied the polymerase chain reaction technique to detect 4.977 bp-deleted mtDNA, the most common and abundant deletion of mtDNA, in normal human skin....
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aging
- Base Sequence
- Child
- Child, Preschool
- DNA, Mitochondrial
- Gene Deletion
- Humans
- Infant
- Infant, Newborn
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Skin