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Article

Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing.

Nucleic acids research - 1 Mar 1998

Liu V W, Zhang C, Nagley P

Abstract excerpt

In 60 human tissue samples (encompassing skeletal muscle, heart and kidney) obtained from subjects aged from under 1 to 90 years, we used quantitative PCR procedures to quantify mitochondrial DNA (mtDNA) molecules carrying the 4977 bp deletion (mtDNA4977) and 3243 A-->G base substitution. In addi...

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Identifiers

PMID: 9469836
DOI: 10.1093/nar/26.5.1268
PMCID: PMC147381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9469836-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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