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Article

A study of mitochondrial DNA mutations in peripheral lymphocytes in an aging cohort.

Biochemical Society transactions - 1 Apr 2003

Zhang B, Ye S, Sayer A A, Hammans S R, Adio S, Hinks L J, Smythe P J, Groot D, Cooper C, Day I N M

Abstract excerpt

Somatic mutation in the mitochondrial genome occurs much more rapidly than in the nuclear genome and is a feature, possibly contributory, of the aging of cells and tissues. Identifying mitochondrial sequence changes in blood DNA of elderly subjects may provide a maker for the epigenetic changes of mitochondrial DNA known to occur in tissues with lower cellular turnover, and would also have implications for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12653657
DOI: 10.1042/bst0310444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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