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Article

Deleterious mitochondrial DNA mutations accumulate in aging human tissues.

Mutation research - 1 Sept 1992

Arnheim N, Cortopassi G

Abstract excerpt

This paper reviews the current state of knowledge of the contribution of mitochondrial DNA (mtDNA) mutations to the phenotype of aging. Its major focus is on the discovery of deletions of mtDNA which previously were thought to occur only in individuals with neuromuscular disease. One particular deletion (mtDNA4977) accumulates with age primarily in non-dividing cells such as muscle and brain of normal...

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PMID: 1383758
DOI: 10.1016/0921-8734(92)90020-p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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