Deleterious mitochondrial DNA mutations accumulate in aging human tissues.

doi:10.1016/0921-8734(92)90020-p

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Article

Deleterious mitochondrial DNA mutations accumulate in aging human tissues.

Mutation research - 1 Sept 1992

Arnheim N, Cortopassi G

Abstract excerpt

This paper reviews the current state of knowledge of the contribution of mitochondrial DNA (mtDNA) mutations to the phenotype of aging. Its major focus is on the discovery of deletions of mtDNA which previously were thought to occur only in individuals with neuromuscular disease. One particular d...

Topics

Aging
DNA, Mitochondrial
Heart
Humans
Mutation
Polymerase Chain Reaction
Sequence Deletion

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