Article
The impact of mitochondrial DNA on human lifespan: a view from studies on centenarians.
Biotechnology journal - 1 Jun 2008
Salvioli Stefano, Capri Miriam, Santoro Aurelia, Raule Nicola, Sevini Federica, Lukas Stella, Lanzarini Catia, Monti Daniela, Passarino Giuseppe, Rose Giuseppina, De Benedictis Giovanna, Franceschi Claudio
Abstract excerpt
The role of inherited and somatic mutations of mitochondrial DNA (mtDNA) in aging and longevity is complex and highly controversial, owing to its peculiar genetics, including the phenomenon of heteroplasmy. Most of the data on mtDNA and longevity have been obtained on humans and particularly on centenarians, i. e., people who escaped or delayed the major age-related pathologies and reached the extreme limit of...
Topics
- Aged, 80 and over
- DNA, Mitochondrial
- Humans
- Longevity
- Models, Genetic
- Mutation