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Article

Retinoblastoma gene deletions in human glioblastomas.

Oncogene - 1 Mar 1991

Venter D J, Bevan K L, Ludwig R L, Riley T E, Jat P S, Thomas D G, Noble M D

Abstract excerpt

The retinoblastoma susceptibility gene, RB, is the best characterised of the tumour suppressor genes, or 'anti-oncogenes'. Abnormal function of the RB protein is thought to result in loss of an inhibitory effect on cell growth, and thus contribute towards the development of certain human cancers. One group of human cancers of particular interest in relationship to retinoblastoma gene function are the gliomas,...

Topics

Alleles
Blotting, Northern
Blotting, Southern
Chromosome Deletion
DNA
DNA Probes
Genes, Retinoblastoma
HeLa Cells
Heterozygote
Homozygote
Humans
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retinoblastoma

Retinoblastoma Protein

Source

Identifiers

PMID: 2011399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2011399-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Retinoblastoma gene deletions in human glioblastomas.PMID 2011399Read ↗

Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas.Semantic proximity Read ↗

Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene.Semantic proximity Read ↗

Characterization of intragenic deletions in two sporadic germinal mutation cases of retinoblastoma resulting in abnormal gene expression.Semantic proximity Read ↗

The retinoblastoma gene in human pituitary tumors.Semantic proximity Read ↗

Structural alterations at the putative retinoblastoma locus in some human leukemias and preleukemia.Semantic proximity Read ↗

Mutations of the retinoblastoma gene in human lymphoid neoplasms.Semantic proximity Read ↗

The retinoblastoma gene is involved in malignant progression of astrocytomasSemantic proximity Read ↗

Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas.Semantic proximity Read ↗

Molecular karyotype of sporadic unilateral retinoblastoma tumors.Semantic proximity Read ↗

Frequency of IFN beta 1 gene loss in 47 primary human gliomas.Semantic proximity Read ↗

Deletion of the human retinoblastoma gene in primary leukemias.Semantic proximity Read ↗

Accumulation of genetic defects during astrocytoma progression.Semantic proximity Read ↗

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